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Recurrent Toxin-Mediated Perineal Erythema: Eleven Pediatric Cases

Andrés Carvajal1, Romina Cabrera1, Margarita Larralde1,2

  • 1Pediatric Dermatology Section, Hospital General de Agudos J. M. Ramos Mejía, Buenos Aires, Argentina.

Pediatric Dermatology
|April 13, 2026
PubMed

Insights

Recurrent toxin-mediated perineal erythema (RTMPE) is a skin condition in children. Early diagnosis and oral antibiotic treatment showed good results in pediatric patients.

Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Microbiology

Background:

  • Recurrent toxin-mediated perineal erythema (RTMPE) is a T-lymphocyte response to bacterial toxins.
  • While often seen in adolescents, pediatric RTMPE cases are rising.
  • Staphylococcus aureus and Streptococcus pyogenes are implicated bacterial culprits.

Purpose of the Study:

  • To describe RTMPE in pediatric patients.
  • To evaluate the response to oral antibiotic therapy in children with RTMPE.

Main Methods:

  • Retrospective case series.
  • Eleven pediatric patients diagnosed with RTMPE were identified.
  • Treatment and outcomes were reviewed.

Main Results:

  • Eleven pediatric patients with RTMPE were identified.
  • All patients showed a good response to oral antibiotic treatment.
  • No significant adverse events were reported.

Conclusions:

  • RTMPE is increasingly recognized in pediatric populations.
  • Oral antibiotics are an effective treatment for pediatric RTMPE.
  • Prompt diagnosis and treatment are crucial for favorable outcomes.

Keywords:
pediatricsperineal erythematoxins

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