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Updated: Apr 14, 2026
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Effect of Preoperative Ibuprofen on Pain Perception and Pulse Rate in Paediatric Patients with Deep Caries: A
1Inonu University, Faculty of Dentistry, Department of Pedodontics, Malatya, Türkiye.
Aim:
To evaluate the effect of preoperative ibuprofen on intraoperative pain and stress responses during vital pulp therapy (VPT), a minimally invasive treatment aimed at preserving pulp vitality, in children with reversible pulpitis.
Methods:
Forty-four children aged 7-13 years with reversible pulpitis in mandibular first permanent molars were randomly assigned to either the intervention group (10 mg/kg ibuprofen 40 minutes before treatment, n = 22) or the control group (no premedication, n = 22). Pain was assessed intraoperatively using the Visual Analogue Scale (VAS) and pulse rate monitoring. Postoperative VAS scores were recorded on days 1, 3, and 7. Ethical approval was obtained (Approval No: 2024-KAEK-08; 25.12.2024), and the study was registered at ClinicalTrials.gov (NCT07114198).
Conclusion:
Preoperative administration of ibuprofen significantly reduces intraoperative pain and stress responses during VPT in children, improving comfort and cooperation, and may serve as a simple and clinically applicable adjunct in routine paediatric dental practice.
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