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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Published on: September 27, 2024

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Remnant Cholesterol Inflammatory Index and Its Association With All-Cause Mortality Among General Population and

Chen-Zhang Ou1, Zhong-Qiang Liu2, Yu-Jun Xiong3

  • 1Department of Urology, Jiangnan University Medical Center, Wuxi No.2 People's hospital, Wuxi, Jiangsu, China.

Clinical Cardiology
|April 13, 2026
PubMed

Insights

The remnant cholesterol inflammatory index (RCII) effectively predicts mortality risk in early cardiovascular-kidney-metabolic (CKM) stages 0-3. This index shows superior performance compared to other metabolic markers for identifying individuals at higher risk.

Area of Science:

  • Cardiovascular health
  • Metabolic syndrome research
  • Mortality risk assessment

Background:

  • Early identification of mortality risk in cardiovascular-kidney-metabolic (CKM) stages 0-3 is difficult.
  • The prognostic value of the remnant cholesterol inflammatory index (RCII) in these early stages is not well-understood.

Purpose of the Study:

  • To evaluate the remnant cholesterol inflammatory index (RCII) as a predictor of all-cause mortality in early CKM stages.
  • To compare the performance of RCII against established metabolic indices.

Main Methods:

  • Analysis of two large, nationally representative cohorts: NHANES (U.S.) and CHARLS (China).
  • Utilized Cox regression, ROC analyses, and restricted cubic splines to assess RCII's association with mortality.
  • Stratified analyses were performed based on CKM stages.

Main Results:

  • Higher RCII levels were consistently linked to increased all-cause mortality in the general population and CKM stages 0-3.
  • RCII demonstrated superior discriminatory ability for mortality prediction compared to other metabolic indices.
  • Associations remained significant after multivariable adjustments, particularly in the highest RCII category.

Conclusions:

  • The remnant cholesterol inflammatory index (RCII) serves as a potent and independent predictor of all-cause mortality.
  • RCII is valuable across diverse populations and early CKM stages (0-3).
Abstract

Keywords:
RCIIall‐cause mortalitycardiovascular–kidney–metabolic syndromemetabolic parameters

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