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Related Experiment Video

Updated: Jul 3, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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Exercise testing for evaluating right ventricular (RV) function in pulmonary hypertension - A review.

Talha Farooq1, Maryam Mohsin, Wajiha Fatima

  • 1MBBS, Jinnah Sindh Medical University, Karachi, Pakistan.

Lung India : Official Organ of Indian Chest Society
|April 13, 2026
PubMed
Summary

Exercise testing is vital for assessing right ventricular (RV) function in pulmonary hypertension (PH). It aids in diagnosis and prognosis by evaluating RV dysfunction and guiding treatment decisions.

Keywords:
CPETRV dysfunctionexercise testingpulmonary hypertensionright ventricular function

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Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Exercise Physiology

Background:

  • Right ventricular (RV) dysfunction is central to pulmonary hypertension (PH) pathophysiology.
  • Accurate assessment of RV function is critical for PH diagnosis and prognosis.
  • Exercise limitation is a common symptom in PH patients due to impaired RV function.

Purpose of the Study:

  • To review and discuss exercise testing modalities for evaluating RV function in PH.
  • To highlight the diagnostic and prognostic utility of exercise testing in PH management.
  • To synthesize current knowledge on how exercise reveals RV dysfunction in PH.

Main Methods:

  • Comprehensive literature search of PubMed and Google Scholar.
  • Inclusion of keywords: pulmonary hypertension, right ventricular function, exercise testing, CPET, RV dysfunction, hemodynamic assessment, right heart failure, exercise limitation.
  • Narrative review synthesizing findings on exercise testing and RV function in PH.

Main Results:

  • RV dysfunction in PH involves maladaptive remodeling and impaired systolic/diastolic function.
  • Exercise testing parameters like reduced VO2 max, altered O2 pulse, and decreased RV stroke volume indicate RV dysfunction.
  • Ventilatory abnormalities (VE/VCO2 slope, petCO2) and RV-arterial coupling (Ees/Ea) offer insights into RV performance.
  • Exercise-induced changes in pulmonary artery systolic pressure (PASP) are prognostically significant.

Conclusions:

  • Exercise testing offers a comprehensive assessment of RV function in PH.
  • It provides crucial diagnostic and prognostic information for PH patients.
  • Integrating exercise test parameters aids in assessing RV reserve and guiding therapeutic strategies.