Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

4.9K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Keratin 5 expression defines a niche-supported hierarchy in tubo-ovarian cancer.

Cancer heterogeneity and plasticity·2026
Same author

DDX5 (p68) and UbE2T as emerging superior cancer therapeutic targets: dual molecular glue target degradation by FL118 for conquering difficult-to-treat cancers.

Journal of experimental & clinical cancer research : CR·2026
Same author

Biomarkers with Therapeutic or Prognostic Applications in Gynecologic Malignancies.

Cancers·2026
Same author

Use of Parent- and Patient-Reported Outcome Measures in Pediatric Specialty Clinics: A Pilot Randomized Clinical Trial.

JAMA network open·2026
Same author

Author Correction: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.

Nature·2025
Same author

Navigating Solid Tumor Heterogeneity: The Promise and Challenges of Antibody-Drug Conjugates.

Cancer heterogeneity and plasticity·2025

Related Experiment Video

Updated: Apr 14, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.8K

Endometrial Cancer: A Review.

Katherine L Mager1, Karen McLean1,2

  • 1Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

JAMA
|April 13, 2026
PubMed
Summary

Endometrial cancer, the most common uterine cancer, is rising in incidence, particularly in younger women, linked to obesity. Treatment involves surgery, radiation, and chemotherapy, with survival rates varying by stage.

More Related Videos

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

14.0K
Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
05:42

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Published on: January 26, 2024

3.4K

Related Experiment Videos

Last Updated: Apr 14, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.8K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

14.0K
Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
05:42

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Published on: January 26, 2024

3.4K

Area of Science:

  • Gynecologic Oncology
  • Cancer Epidemiology
  • Medical Treatment

Background:

  • Endometrial cancer constitutes 95% of uterine cancers and is the fourth most common cancer in US women.
  • Rising obesity rates correlate with increased endometrial cancer incidence, alongside a concerning rise in younger women.
  • Mortality rates are increasing, with significant disparities observed between Black and White women.

Purpose of the Study:

  • To summarize the current understanding of endometrial cancer epidemiology and treatment.
  • To highlight trends in incidence and mortality, including demographic disparities.
  • To outline the standard management strategies for endometrial cancer.

Main Methods:

  • Review of epidemiological data on incidence and mortality trends.
  • Description of diagnostic methods, including biopsy and D&C.
  • Outline of treatment modalities: surgery, radiation, chemotherapy, and immunotherapy.

Main Results:

  • Endometrial cancer incidence is increasing, especially in younger age groups (20-39 years).
  • Obesity is a significant risk factor, correlating with rising incidence.
  • Significant racial disparities exist in mortality rates.
  • Treatment success varies by stage, with >86% 5-year survival for Stage I and >18% for Stage IV.

Conclusions:

  • Endometrial cancer requires urgent attention due to rising incidence and mortality.
  • Multimodal treatment including surgery, radiation, and chemotherapy is crucial.
  • Addressing disparities and risk factors like obesity is essential for improving outcomes.