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Pediatric Meningiomas: Clinicopathological Spectrum, Long-Term Outcomes, and Recurrence Predictors.
Jeena Joseph1, Swaminathan Ganesh1, Krishnaprabhu Raju2
1Department of Neurosurgery, Christian Medical College and Hospital, Ranipet, India.
Pediatric Neurosurgery
|April 13, 2026
Summary
Pediatric meningiomas are rare, aggressive tumors with a high recurrence risk. The MIB-1 labelling index and longer follow-up predict recurrence, emphasizing biomarker use and surveillance.
Area of Science:
- Pediatric neuro-oncology
- Neurosurgery
- Cancer biology
Background:
- Pediatric meningiomas are rare, distinct from adult types.
- Management requires understanding unique clinical and biological features.
- Tertiary referral centers manage these complex cases.
Purpose of the Study:
- To review a 20-year experience with pediatric meningiomas.
- To analyze clinical characteristics, pathology, and outcomes.
- To identify prognostic factors for recurrence.
Main Methods:
- Retrospective analysis of 47 pediatric patients (<18 years).
- Data collection: demographics, presentation, radiology, pathology, treatment, outcomes.
- Statistical analysis: Kaplan-Meier for recurrence, univariate/multivariate analysis for predictors.
Main Results:
- Pediatric meningiomas: 3.9% of all meningiomas.
- Median age 13 years; 55.3% female; 21% with neurofibromatosis.
- 61.7% were high-grade (WHO II/III); 21.3% recurrence rate.
- MIB-1 index and longer follow-up predicted recurrence.
Conclusions:
- Pediatric meningiomas show aggressive pathology and high recurrence risk.
- MIB-1 index and follow-up duration are independent predictors of recurrence.
- Biomarker risk stratification and extended surveillance are crucial for management.
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