Feasibility of Internet-Based Mind-Body Training for Adults With Subjective Cognitive Decline: Protocol for a...

Area of Science:

• Neuroscience
• Gerontology
• Preventative Medicine

Background:

• Alzheimer's disease (AD) prevalence is projected to double in the US, costing $1 trillion annually.
• Healthy lifestyle behaviors may reduce dementia rates by 45%, especially in preclinical stages.
• Subjective cognitive decline (SCD) is a potential indicator of preclinical AD.

Purpose of the Study:

• Evaluate the feasibility and acceptability of an internet-based mindfulness program for SCD.
• Compare mindfulness intervention to an internet-based lifestyle education control group.
• Examine preliminary effects on SCD, AD biomarkers (amyloid, tau), and mind-wandering.

Main Methods:

• Randomized controlled trial with 60 adults aged 50+ screened for SCD.
• Participants undergo baseline and post-8-week intervention assessments, including cognitive tasks and blood draws.
• Randomization to either an internet-based mindfulness or lifestyle education program.

Main Results:

• Recruitment for the internet-based mind-body training trial began in June 2025 and is ongoing.
• Data collection is expected to conclude in December 2026.
• Phase 1 focused on program development based on focus group feedback.

Conclusions:

• Online, experiential interventions show promise for cognitive health maintenance.
• Internet-based programs overcome barriers like accessibility and time constraints.
• Future studies are needed to confirm efficacy for AD biomarkers and cognitive outcomes.