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Related Concept Videos

DNA Packaging00:58

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DNA isolation protocols can be fast and straightforward or complex and time-consuming depending on the type and quality of DNA required for further processing. For example, plasmid DNA extraction is a bit more complicated than genomic DNA extraction because of the need for an appropriate lysis method to separate plasmid DNA from gDNA during isolation. However, for specific applications, such as long-range DNA sequencing that require a good yield of high- quality DNA samples, we need to follow...
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Updated: May 31, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Toward Portable DNA Data Storage: A Paper-Based System for Rewritable and Random Access.

Qian Liu1,2, Jie Zhang1,2, Jingsong Cui3

  • 1School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300350, China.

ACS Applied Materials & Interfaces
|April 13, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a portable cellulose paper platform for DNA data storage, enabling random data access at room temperature. This low-cost method offers a practical solution for high-density, long-term data archiving.

Keywords:
DNA data storageDNA immobilizationlow costpaperportablerandom and repeated access

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Area of Science:

  • Biotechnology
  • Data Storage
  • Materials Science

Background:

  • DNA offers high-density, long-term data archival potential.
  • Current DNA data storage methods face challenges in portability and random data access.
  • Existing techniques often require specialized, bulky laboratory equipment.

Purpose of the Study:

  • To develop a low-cost, portable platform for DNA data storage using cellulose paper.
  • To enable random access to DNA data stored on cellulose paper at room temperature.
  • To demonstrate the reusability of the cellulose paper platform for repeated data writing and reading.

Main Methods:

  • Immobilizing DNA pools containing distinct files onto cellulose paper sheets.
  • Assigning physical addresses to DNA locations for array preservation and random access.
  • Utilizing a constant-temperature amplification reaction for in situ random data access.
  • Employing the magnetic bead method for DNA pool recovery and repeated data operations.

Main Results:

  • Successful immobilization and preservation of DNA data on cellulose paper.
  • Achieved in situ random data access at room temperature, eliminating the need for thermocyclers.
  • Demonstrated successful recovery of the original DNA pool using magnetic beads.
  • Enabled three cycles of data writing and reading on the cellulose paper surface.

Conclusions:

  • Cellulose paper is a viable, low-cost medium for practical and portable DNA data archiving.
  • The developed method overcomes limitations of portability and random access in DNA data storage.
  • This approach presents a promising solution for massive data storage challenges.