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Rheumatology: What You May Have Missed in 2025.
1Division of Rheumatology, Hospital for Special Surgery, and Weill Cornell Graduate School of Medical Sciences, New York, New York (A.D.L.).
Annals of Internal Medicine
|April 13, 2026
Summary
Internal medicine physicians can improve rheumatic condition management with new insights on gout, osteoarthritis, and rheumatoid arthritis treatments. Key findings include optimal gout strategies and the impact of diet and exercise on osteoarthritis.
Area of Science:
- Rheumatology
- Internal Medicine
- Clinical Research
Background:
- Internal medicine physicians frequently serve as the initial point of contact for patients with rheumatic conditions.
- Collaboration between internal medicine specialists and rheumatologists is crucial for comprehensive patient care.
- Keeping abreast of recent rheumatology literature is essential for non-specialist physicians managing rheumatic diseases.
Purpose of the Study:
- To review six key rheumatology studies from 2025 relevant to internal medicine physicians.
- To highlight recent advancements in the management of gout, osteoarthritis, and rheumatoid arthritis.
- To provide actionable insights for internists managing patients with rheumatic conditions.
Main Methods:
- Systematic review and summary of six selected studies published in rheumatology journals in 2025.
- Studies focused on treat-to-target urate strategy, diet and exercise interventions for hip osteoarthritis, physical activity and knee osteoarthritis incidence, nonarticular pain in rheumatoid arthritis, metformin for knee osteoarthritis, and anti-inflammatory drugs versus colchicine in gout management.
Main Results:
- A treat-to-target urate strategy is effective for gout management.
- Very-low-calorie diets combined with exercise show benefits for hip osteoarthritis.
- Purposeful walking step counts correlate with symptomatic knee osteoarthritis incidence.
- Nonarticular pain significantly impacts quality of life in early rheumatoid arthritis.
- Metformin demonstrates potential in improving knee osteoarthritis symptoms and function.
- NSAIDs and colchicine have comparable efficacy in preventing gout flares during urate-lowering therapy initiation.
Conclusions:
- Recent rheumatology research offers valuable updates for internal medicine physicians.
- Evidence supports specific dietary and exercise interventions for osteoarthritis.
- Understanding the impact of nonarticular pain is important in rheumatoid arthritis care.
- New therapeutic options and management strategies for gout and osteoarthritis are emerging.
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