An immunosensor based on Cu doping enhanced Gd MOF electrochemiluminescence was used to detect CA19-9

In this work, Gd MOF was designed with Gd (III) as the central metal ion and 5-aminoisophthalic acid (5-AIPA) as the organic ligand, and its electrochemiluminescence (ECL) performance was investigated. At the same time, considering the reversible conversion of Cu²⁺/Cu⁺, Cu doping of Gd MOF can effectively reduces the charge transfer resistance and accelerates the electron transfer process, the ECL intensity of Gd MOF is significantly enhanced. In addition, by further calcination of Cu MOF epitaxial growth In MOF to obtain CuO@In₂O₃ composite material with internal hollow structure as co-reaction promoter. A Cu:Gd MOF/S₂O₈^2-/CuO@In₂O₃ ternary system was constructed and the ECL intensity was further enhanced. By monitoring the change of ECL strength, the target analyte CA19-9 can be quantitatively detected, that is, CA19-9 can be quantitatively analyzed through the enhancement of ECL intensity, and the constructed sandwich-type ECL immunosensor achieves sensitive and accurate detection of CA19-9.