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Updated: Apr 15, 2026
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
Published on: April 11, 2025
Novel Neuroimaging Biomarker of Cortical Gray/White Border Integrity in Blast-Related Mild Traumatic Brain Injury
V Carlota Andreu Arasa1,2,3, Francesca C Fortebaugh4,2,5, Aubrey A Knoff4,5,6
1From the Translational Research Center for TBI and Stress Disorders (TRACTS) (V.C.A.A., F.C.F., A.A.K., C.B.F., W.P.M., D.H.S.), VA Boston Healthcare System, Boston, Massachusetts vanesa.andreuarasa@va.gov.
Background And Purpose:
Recent studies suggest that blast or mid-impact neurotrauma are characterized by scar-border forming astrogliosis at the gray-white matter junction. Individuals with mild traumatic brain injury (mTBI) and blast trauma have increased neuroinflammation and impairment of axonal remyelination on postmortem histopathology. However, there are currently only limited methodologies to use in the assessment of the cortical gray/white interface using in vivo neuroimaging. The purpose was to investigate the gray-white matter contrast (GWC) at the gray-white matter junction that may be linked to neuroinflammation/astrogliosis in the setting of blast exposure and/or mTBI, through 3D T1-weighted MPRAGE images.
Materials And Methods:
Post-9/11 veterans (n=723) from the Translational Research Center for TBI and Stress Disorders completed MRI. Participants were grouped into 4 categories: participants with a history of blast-related mTBI (blast-mTBI), participants with a history of mTBI due to other mechanical forces (blunt-mTBI), participants with a history of close blast exposure but no mTBI, and those without a history of lifetime mTBI or close blast exposure. MRI data processing for morphometry and cortical surface mapping was done using FreeSurfer image analysis. Signal intensities in gray and white matter along the cortical and white matter interface were used to calculate mean GWC value.
Results:
Veterans in the blast-mTBI group showed diffuse patterns of increased GWC relative to the other groups, particularly in the frontotemporal lobes. This effect was driven primarily by a greater number of high GWC regions in the blast-mTBI group compared with the no-neurotrauma and blunt-mTBI groups.
Conclusions:
There was diffuse increased GWC on MR in the blast-mTBI group compared with the no-neurotrauma, close blast exposure, and blunt-mTBI groups. These findings may be linked to astrogliosis and neuroinflammation in patients with blast-mTBI. Histopathologic correlation with imaging findings will be necessary to better understand these effects.
