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Related Concept Videos

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Related Experiment Video

Updated: Jul 16, 2026

The Tail Suspension Test
10:17

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TST Score Helper: An Open-Source Graphical User Interface for Assisted Manual Scoring of the Tail Suspension Test.

Sydney E Triplett1, Chenxing Li1, Paul Sanz2

  • 1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, Georgia 30318.

Eneuro
|April 13, 2026
PubMed
Summary

Manual scoring of the tail suspension test (TST) can be error-prone. A new graphical user interface, TST Score Helper, streamlines scoring and improves the reliability of results for behavioral studies.

Keywords:
GUIMATLAB GUIbehavioral testingmousetail suspension test

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Animal Models

Background:

  • The tail suspension test (TST) is a standard method for assessing depressive-like behavior in rodents.
  • Manual scoring of TST is preferred by researchers for accuracy but is prone to significant errors.
  • Existing automated scoring programs do not fully address the needs of researchers preferring manual assessment.

Purpose of the Study:

  • To develop a novel graphical user interface (GUI) to assist in manual TST scoring, minimizing errors.
  • To enhance the rigor and reliability of TST data collection through a user-friendly tool.
  • To provide a solution for researchers seeking to improve the accuracy of manual TST analysis.

Main Methods:

  • Development of a GUI named "TST Score Helper" consolidating the TST scoring procedure.
  • Implementation of a "rescore mode" for comparing scorer timelines and resolving disagreements.
  • Validation of the TST Score Helper using data from 64 male and 45 female mice subjected to closed head injury or sham injury.

Main Results:

  • The TST Score Helper effectively minimizes common sources of manual scoring error.
  • The GUI enhances the fidelity and consistency of TST data.
  • The rescore mode facilitates objective comparison and review of scorer judgments, improving inter-rater reliability.

Conclusions:

  • The TST Score Helper is a valuable tool for improving the accuracy and reliability of manual tail suspension test scoring.
  • This novel GUI addresses the limitations of traditional manual scoring methods in behavioral research.
  • Implementing the TST Score Helper can lead to more robust and reproducible findings in stress and depression research.