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Updated: Apr 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Cellular and molecular mechanisms of systemic sclerosis: Translation to targeted therapies and clinical practice
Diane Documet1, Sophia Ruser1, Crystal Cheung1
1Department of Internal Medicine, Section of Rheumatology, Allergy & Immunology, Yale School of Medicine, 300 Cedar Street TAC S 470 A, New Haven, CT, 06519, USA.
Abstract:
Systemic sclerosis (SSc) is characterized by profound clinical heterogeneity due to dysregulated communication between vascular, immune, and stromal compartments. This review synthesizes genetic and epigenetic determinants of SSc with observations from transcriptomic, proteomic, and metabolomic studies. We highlight emerging cellular- and molecular-level insights into vasculopathy, immune dysregulation, and fibroblast activation in SSc. Finally, we discuss how these mechanistic discoveries inform the development of targeted, precision-medicine based therapeutic approaches in SSc.
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