Related Experiment Video
Updated: Apr 15, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Autoimmune gastritis: emerging insights and clinical management
Marco Vincenzo Lenti1,2, Emanuela Miceli3, Alessandro Vanoli4,5
1Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy. marco.lenti@unipv.it.
Abstract:
Autoimmune gastritis (AIG) is an immune-mediated condition that affects the oxyntic mucosa of the stomach, leading to progressive atrophy and deficiencies in vitamin B12, iron and other micronutrients. Our understanding of the pathogenesis, clinical manifestations and management of AIG has improved in the past 20 years. Initially thought to be associated mainly with pernicious anaemia and limited to certain geographical areas, AIG is now recognized as a global disorder with a broad clinical spectrum, ranging from asymptomatic cases to gastrointestinal, haematological, neurological and gynaecological manifestations. The role of Helicobacter pylori in the development of AIG has been debated, with evidence suggesting that AIG might arise through distinct pathogenic pathways both related and unrelated to H. pylori infection. The risk of gastric adenocarcinoma in AIG has also been reassessed on the basis of studies exploring its natural history. Finally, novel insights have emerged regarding the characterization of 'potential AIG' and 'seronegative AIG', two distinct conditions that were previously overlooked. In this Review, we discuss the latest advances in the field of AIG.
Related Concept Videos
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Acute Pancreatitis II: Clinical Manifestations and Management
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
