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Published on: November 20, 2015
Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study
Anurag Fursule1, Gayatri Athalye-Jape1,2, Diksha Deepak1
1Neonatal Directorate, King Edward Memorial Hospital for Women, Perth, WA, Australia.
Objective:
To assess whether early hypernatremia (HN) and/or hyperglycemia (HG) in the first postnatal week are associated with adverse neurodevelopmental outcomes in extremely preterm (EP; <28 weeks) infants.
Study Design:
This was a single-center retrospective cohort study. HN is defined as serum sodium > 145 mmol/L and HG as blood glucose > 10 mmol/L within days 0-7. Infants were classified into HN, HG, or combined HN + HG groups; EP infants without HN/HG served as controls. This study included 748 EP infants: 374 with HN and/or HG and 374 controls. The primary outcome was an adverse neurodevelopmental outcome at 2 years' corrected age.
Results:
On adjusted analyses, HN, HG and HN + HG were not associated with moderate-to-severe developmental impairment. Moderate-to-severe HN group showed a lower odds of moderate-to-severe developmental impairment than controls (18.3% vs 21.5%; adjusted OR 0.39, 95% CI 0.15-0.99; p = 0.047).
Conclusions:
Early hypernatremia and/or hyperglycemia were not associated with adverse neurodevelopment at 2 years' corrected age.
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