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  3. Association Between Occupation And Cancer Risk: A Large-scale Case-control Study In Japan.
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  3. Association Between Occupation And Cancer Risk: A Large-scale Case-control Study In Japan.

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Association Between Occupation and Cancer Risk: A Large-Scale Case-Control Study in Japan.

Kota Fukai1, Shoko Nakazawa1, Kosuke Sakai1

  • 1Department of Preventive Medicine, Tokai University School of Medicine, Isehara, Japan.

Journal of Occupational and Environmental Medicine
|April 14, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Occupation is linked to cancer risk in Japan, with manual and transport jobs showing higher risks, especially for men. Professional roles may have lower cancer incidence, varying by cancer type and sex.

Keywords:
Cancer riskCase-control studyDetection biasJapanOccupation

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Area of Science:

  • Epidemiology
  • Occupational Health

Background:

  • Occupational exposures are a significant factor in cancer etiology.
  • Understanding occupation-cancer associations is crucial for public health in Japan.

Purpose of the Study:

  • To investigate the relationship between occupation and overall/site-specific cancer risk in Japan.
  • To identify occupational disparities in cancer incidence.

Main Methods:

  • A multicenter, hospital-based matched case-control study was conducted.
  • Data from 146,994 cancer cases and 278,244 controls (2005-2023) were analyzed.
  • Conditional logistic regression estimated sex-specific odds ratios for various occupations.

Main Results:

  • Significant occupational disparities in cancer risk were observed.
  • Men in manual and transport occupations faced elevated cancer risks.
  • Certain professional occupations were associated with lower cancer risks, with variations by cancer site and sex.

    • Conclusions:

    • Occupation is demonstrably associated with cancer risk in Japan.
    • Distinct sex-specific and site-specific patterns highlight the importance of occupational context.
    • Findings suggest behavioral and detection factors influencing cancer risk across occupations.