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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Related Experiment Video

Updated: May 27, 2026

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
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Pilot Study on Dynamic Long-Axial Field-of-View [18F]FDG PET/CT in Liver Transplant Recipients as a Non-Invasive

Martin Bloch1, Susanne Dam Nielsen2,3, Barbara Malene Fischer1

  • 1Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, 2100 Copenhagen, Denmark.

Diagnostics (Basel, Switzerland)
|April 14, 2026
PubMed
Summary

Dynamic [18F]FDG PET/CT shows altered hepatic kinetics in liver transplant recipients, unrelated to inflammation. These findings may impact [18F]FDG PET interpretation, necessitating further research into this non-invasive monitoring method.

Keywords:
allograft inflammationhepatic [18F]FDG kineticsliver transplantationlong-axial field-of-view [18F]FDG PET/CT

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Area of Science:

  • Nuclear Medicine
  • Transplant Surgery
  • Radiochemistry

Background:

  • Liver biopsy is standard for monitoring liver allografts but carries risks.
  • Dynamic long-axial field-of-view (LAFOV) [18F]FDG PET/CT is explored as a non-invasive alternative.
  • Assessing feasibility of advanced PET/CT imaging in liver transplant recipients.

Purpose of the Study:

  • Evaluate dynamic LAFOV [18F]FDG PET/CT for non-invasive monitoring of liver allografts.
  • Compare hepatic kinetic parameters between liver transplant recipients and healthy controls.
  • Investigate correlation between PET/CT parameters and biopsy-proven inflammation (BANFF score).

Main Methods:

  • Prospective enrollment of liver transplant recipients (LTx) and healthy controls.
  • Dynamic LAFOV [18F]FDG PET/CT imaging followed by liver biopsy in LTx recipients.
  • Analysis of hepatic kinetic parameters (K1, k2, k3, k4) and SUVmean/SUVmax; statistical comparisons using Mann-Whitney U and Spearman's rank correlation.

Main Results:

  • LTx recipients exhibited significantly higher k3 and k4 kinetic parameters compared to controls.
  • No significant correlations were found between BANFF scores and kinetic parameters.
  • Elevated k3/k4 values in LTx recipients were not explained by allograft inflammation.

Conclusions:

  • Altered hepatic [18F]FDG kinetics are present in liver transplant recipients, independent of inflammation.
  • These kinetic changes may interfere with [18F]FDG PET imaging interpretation.
  • Larger studies are required to determine the clinical utility of dynamic LAFOV [18F]FDG PET/CT for allograft monitoring.