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Rutin as a Potential Therapeutic Agent for Multi-Organ Ischemia-Reperfusion Injury: From Multidimensional Mechanisms
Quan Peng1, Yancheng Zhong1, Xiaoxu Yang1
1Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese Medicine and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.
Molecules (Basel, Switzerland)
|April 14, 2026
Summary
Rutin demonstrates protective effects against ischemia-reperfusion injury (IRI) by combating oxidative stress and inflammation. Enhancing rutin
Area of Science:
- Biochemistry
- Pharmacology
- Pathology
Background:
- Ischemia-reperfusion injury (IRI) is a complex pathological process resulting from restoring blood flow after ischemia.
- It involves oxidative stress, inflammation, and mitochondrial dysfunction, posing a significant clinical challenge.
- Current therapeutic strategies for IRI are limited, necessitating novel interventions.
Purpose of the Study:
- To systematically review the molecular mechanisms of rutin's protective effects against IRI.
- To synthesize evidence from preclinical studies on rutin's diverse modes of action in IRI.
- To identify challenges and future directions for the clinical application of rutin.
Main Methods:
- Systematic literature review of preclinical studies on rutin and IRI.
- Analysis of molecular pathways involved in rutin's antioxidant and anti-inflammatory actions.
- Evaluation of evidence for rutin's cytoprotective effects against cell death.
Main Results:
- Rutin exhibits pleiotropic biological activities, including potent antioxidant, anti-inflammatory, and cytoprotective effects.
- Preclinical studies demonstrate rutin's efficacy in mitigating IRI through various molecular mechanisms.
- Rutin's therapeutic potential is significantly limited by its poor bioavailability.
Conclusions:
- Rutin shows considerable promise as a therapeutic agent for IRI due to its multifaceted protective properties.
- Overcoming rutin's low bioavailability is crucial for its successful clinical translation.
- Future research should focus on developing advanced pharmaceutical formulations to enhance rutin's bioavailability and efficacy in IRI treatment.
