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Engineering Strategies of Colloidal Drug Delivery Systems, a Rising Star in Ocular Neovascular Diseases
Yueping Bai1,2, Lu Liu1, Cui Li1
1Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin 300020, China.
Colloidal drug delivery systems (CDDSs) enhance ocular drug bioavailability for neovascular diseases. These nanomedicines overcome barriers for precise, lesion-specific treatment, improving vision outcomes.
Area of Science:
- Ophthalmology
- Nanomedicine
- Drug Delivery
Background:
- Ocular neovascular diseases cause irreversible vision loss.
- Ocular barriers limit conventional treatment efficacy.
Purpose of the Study:
- Review advances in colloidal drug delivery systems (CDDSs) for ocular neovascular diseases.
- Focus on overcoming physiological barriers and achieving lesion-specific delivery.
Main Methods:
- Systematic review of recent research on CDDSs.
- Analysis of design strategies and mechanisms for enhanced ocular drug delivery.
Main Results:
- CDDSs improve ocular drug bioavailability and treatment precision.
- Integration of sustained release, active targeting, and stimulus-responsive modules.
Conclusions:
- CDDSs offer innovative solutions for ocular neovascular diseases.
- Key challenges in clinical translation are identified.
- Advancements promise improved visual prognosis and quality of life.
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