Related Experiment Video
Updated: Apr 15, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Structure-Activity Relationships of Hemocompatible Cationic 6-Azaindole Pyridinium Salts: Antimicrobial and
Roxana Ciorteanu1,2, Ioana C Marinas3, Catalina Ionica Ciobanu4
1ICI-RECENT AIR Center, Alexandru Ioan Cuza University of Iasi, 11 Carol I, 700506 Iasi, Romania.
Abstract:
A series of 6-azaindole pyridinium derivatives were synthesized, structurally characterized, and evaluated for their antimicrobial (against Staphylococcus aureus, Escherichia coli, and Candida albicans) and anticancer properties (against NCI 60 panel). Hemocompatibility was evaluated using the hemolytic index, while ADME properties were estimated using in silico methods. Structure-activity relationship analysis indicated that para-substitution of the phenyl ring, particularly with halogen or methoxy groups, influences antimicrobial activity, selectivity toward Gram-positive bacteria, and hemocompatibility. Compounds 2b and 2c showed the most notable antimicrobial effects, including inhibition of microbial adhesion at hemocompatible concentrations. Compound 2b exhibited growth inhibition against cancer cells, showing 57% percent growth inhibition (PGI) against the MDA-MB-468 breast cancer cell line at 10 mM. Overall, these results highlight 6-azaindole pyridinium salts as a promising class of compounds for further investigation.
More Related Videos
14:11Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Related Concept Videos
Basicity of Heterocyclic Aromatic Amines
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Diazonium Group Substitution: –OH and –H
EDTA: Chemistry and Properties
Complexation Equilibria: The Chelate Effect
Physical Properties of Amines