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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Apr 15, 2026

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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Photodynamic Therapy-Based Strategies Targeted at Cancer Stem Cells: A Scoping Review.

Beatriz Serambeque1,2, Inês Dias1,2, Catarina Mestre1,2

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Summary
This summary is machine-generated.

Photodynamic therapy (PDT) effectively targets cancer stem cells (CSCs), reducing tumor growth and stemness. However, challenges remain in translating these promising PDT strategies for CSCs into clinical applications.

Keywords:
cancer stem cellsphotodynamic therapyphotosensitizerstemnesstargeted therapies

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Photochemistry

Background:

  • Cancer stem cells (CSCs) drive therapeutic resistance, metastasis, and relapse.
  • Targeting CSCs is crucial for effective cancer treatment.
  • Photodynamic therapy (PDT) shows potential for CSC targeting via reactive oxygen species generation.

Purpose of the Study:

  • To review current evidence on PDT-based strategies targeting CSCs.
  • To identify CSC-associated targets and delivery systems for PDT.
  • To explore nanoplatforms and combination strategies for enhanced PDT efficacy against CSCs.

Main Methods:

  • Comprehensive literature search of Medline, Web of Science, and Embase databases.
  • Inclusion of in vitro, in vivo, and clinical studies on PDT targeting CSCs.
  • Analysis of 37 selected publications.

Main Results:

  • Identified studies focusing on CSC targets, PDT delivery systems, and nanoplatforms.
  • Observed success in reducing CSC viability, tumor growth, and stemness properties.
  • Noted technical and biological constraints limiting clinical translation.

Conclusions:

  • PDT-based approaches demonstrate significant preclinical success in targeting CSCs.
  • Further research is needed to overcome limitations for clinical application.
  • No clinical studies on PDT for CSCs have been reported to date.