Related Experiment Video
Updated: Jul 1, 2026

09:08
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Correction: Seborova et al. Non-Coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial
Karolina Seborova1,2, Radka Vaclavikova1,2, Lukas Rob3
1Toxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic.
Cancers
|April 14, 2026
Abstract:
Following publication [...].
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

