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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Prediction Model for Failed Vacuum Assisted Delivery: A Retrospective Cohort Study.

Itamar Gilboa1, Daniel Gabbai1, Lee Reicher1

  • 1Lis Hospital for Women's Health, Tel Aviv Sourasky Medical Center, Gray Faculty of Medicine, Tel Aviv University, Tel Aviv 6927846, Israel.

Journal of Clinical Medicine
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

This study identified key risk factors for failed vacuum-assisted delivery (VAD), developing a predictive model to aid obstetricians in decision-making and identifying high-risk pregnancies for complicated deliveries.

Keywords:
cesarean deliveryfailurelaboroperative vaginal deliveryprediction modelvacuum assisted delivery

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Clinical Prediction Modeling

Background:

  • Vacuum-assisted delivery (VAD) is a common obstetric procedure.
  • Failed VAD can lead to urgent cesarean delivery (CD) and increased maternal and neonatal morbidity.
  • Predictive tools are needed to identify pregnancies at risk for VAD failure.

Purpose of the Study:

  • To determine risk factors associated with failed vacuum-assisted delivery (VAD).
  • To develop and validate a clinically based predictive model for VAD failure.
  • To aid obstetricians in VAD decision-making and patient counseling.

Main Methods:

  • Retrospective cohort study (2011-2023) at a tertiary medical center.
  • Included singleton pregnancies with a VAD attempt.
  • Defined VAD failure by cup detachments, extraction duration, or conversion to urgent CD.

Main Results:

  • 1.9% of VAD attempts (172/8885) failed, resulting in urgent CD.
  • Identified risk factors: labor induction, deep fetal head station, prolonged second stage, preeclampsia, high birthweight (>3750g), and male fetus.
  • Developed prediction score with good discriminatory performance (AUC 0.723), validated internally (AUC 0.764).

Conclusions:

  • A validated predictive model for VAD failure was developed.
  • The model can assist obstetricians in VAD decision-making and risk stratification.
  • Identifies parturients at higher risk for complicated deliveries, enabling proactive management.