Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Stroke Volume

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Parametric color-coding-derived microvascular transit time may predict infarction and reveals microcirculatory benefits of Tenecteplase in acute ischemic stroke.

Frontiers in neurology·2026

Same author

Exploring attitudes and acceptance of artificial intelligence in multiple sclerosis from the patient perspective.

PLOS digital health·2026

Same author

The use of cladribine tablets in patients with MS beyond the age of 50: experiences from a large tertiary German centre.

Neurological research and practice·2026

Same author

Bubble-test for detection of a patent foramen ovale in young to middle-aged ischemic stroke patients.

Frontiers in neurology·2026

Same author

Radiologic drivers of dysphagia after intracerebral haemorrhage: a flexible endoscopic evaluation of swallowing-guided retrospective analysis on intensive care unit.

Neurological research and practice·2026

Same author

Cerebrovascular Events in Aortic Stenosis: From Native Valve Disease to TAVR-Specific Risk and Prevention.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Variability in Key Physiological Parameters in Neurocritical Stroke Patients: A Multicenter Observational Study.

Omar Alhaj Omar¹, Patrick Schramm^1,2, Tobias Frühwald¹

¹Department of Neurology, University Hospital Giessen and Marburg, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.

Journal of Clinical Medicine

|April 14, 2026

Summary

This summary is machine-generated.

Variability in physiological parameters like blood glucose after stroke had limited impact. Greater blood glucose variability was linked to mortality in hemorrhagic stroke, but overall, in-range variability showed limited short-term prognostic value.

Keywords:

intensive care monitoring stroke variability

More Related Videos

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Related Experiment Videos

Last Updated: Apr 15, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Area of Science:

Neurocritical care
Neurology
Intensive care medicine

Background:

Effective management of physiological parameters is crucial in neurocritical care.
The impact of variability within target ranges for parameters like blood pressure and glucose after stroke is not well understood.
Studies are needed to clarify the prognostic value of physiological parameter variability post-stroke.

Purpose of the Study:

To investigate the association between in-range variability of key physiological parameters and clinical outcomes in patients with acute stroke.
To determine if variability in blood pressure, temperature, blood glucose, and gas exchange impacts outcomes like mortality and ventilation duration.
To assess the prognostic value of physiological parameter variability in neurocritical care settings.

Main Methods:

Multicenter observational study involving nine German neurocritical care units.
Analysis of in-range physiological measurements (blood pressure, temperature, glucose, gas exchange) over 96 hours in 281 stroke patients.
Quantification of variability using the coefficient of variation and evaluation of associations with clinical outcomes via multivariable regression.

Main Results:

Physiological parameter variability peaked within the first 24 hours post-stroke and then stabilized.
Increased variability in blood glucose was associated with higher in-hospital mortality in patients with hemorrhagic stroke (aOR 1.08, p=0.04).
No significant association was found between the variability of other physiological parameters and the evaluated clinical outcomes.

Conclusions:

In-range variability of physiological parameters has limited short-term prognostic value in neurocritical care after stroke.
Findings support current guideline-based management strategies for physiological parameters.
Further research may explore long-term prognostic implications or different variability metrics.