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Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Related Experiment Video

Updated: Apr 15, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
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Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

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Signet-Ring Cell Colorectal Cancer and Signet-Ring Cell Component Colorectal Cancer: Do They Differ in Clinical

Cebrail Akyuz1, Oguzhan Sunamak1, Aytac Selman1

  • 1Department of General Surgery, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey.

Journal of Clinical Medicine
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Signet-ring cell colorectal cancer (SRCC) and colorectal cancer with a signet-ring cell component (SRC) share similar clinical features and survival outcomes. Distant metastasis is a key prognostic factor for both rare colorectal cancer subtypes.

Keywords:
coloncolorectal carcinomaprognosisrectumsignet-ring cell

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Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Signet-ring cell colorectal cancer (SRCC) and colorectal cancer with a signet-ring cell component (SRC) are rare histological subtypes of colorectal cancer.
  • These subtypes are associated with a poor prognosis, but their clinical behavior and survival outcomes are not well-differentiated.
  • This study compares the clinicopathological characteristics and survival of SRCC and SRC to clarify potential differences.

Purpose of the Study:

  • To compare the clinicopathological features of SRCC and SRC.
  • To evaluate and compare the survival outcomes between SRCC and SRC patients.
  • To identify prognostic factors in these rare colorectal cancer subtypes.

Main Methods:

  • Retrospective analysis of colorectal cancer (CRC) patients diagnosed with SRCC or SRC between January 2012 and December 2019.
  • Inclusion of patients who underwent surgical resection for CRC.
  • Analysis and comparison of demographic, clinical, and survival data between SRCC and SRC groups.

Main Results:

  • A total of 32 patients (2.6% of CRC cases) with SRCC or SRC were included.
  • Seven patients experienced synchronous distant metastases, including liver, intra-abdominal, and ovarian sites.
  • No statistically significant difference in overall survival was observed between SRCC and SRC groups (p = 0.534), though SRCC patients were diagnosed at a younger age.

Conclusions:

  • SRCC and SRC exhibit largely similar clinicopathological features and survival outcomes.
  • Younger age at diagnosis was noted in SRCC patients.
  • The absence of significant survival differences should be interpreted cautiously due to the small sample size; distant metastasis remains a critical prognostic factor for both subtypes.