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Bioactive Polysaccharides from Blue Honeysuckle Berries: Structural Properties and Digestive Enzyme Inhibition

Na Ding1, Juan Sun1, Jin Li1

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Blue honeysuckle polysaccharides show significant antioxidant and enzyme inhibitory effects. These compounds may serve as functional ingredients for managing blood sugar and obesity.

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Area of Science:

  • Food Science
  • Biochemistry
  • Nutraceuticals

Background:

  • Polysaccharides are complex carbohydrates with diverse biological activities.
  • Blue honeysuckle (Lonicera caerulea L.) berries are rich in bioactive compounds.
  • Understanding the structure-function relationship of berry polysaccharides is crucial for their application.

Purpose of the Study:

  • To investigate the physicochemical and bioactive properties of polysaccharides from blue honeysuckle berries.
  • To explore their potential as functional food ingredients for health management.

Main Methods:

  • Fourier transform infrared spectroscopy (FTIR) for structural confirmation.
  • High-performance liquid chromatography (HPLC) for monosaccharide profiling.
  • High-performance gel permeation chromatography (HPGPC) for molecular weight determination.
  • In vitro assays for antioxidant capacity and enzyme inhibition (pancreatic lipase, α-amylase, α-glucosidase).

Main Results:

  • Blue honeysuckle polysaccharides were identified as acid heteropolysaccharides.
  • Key monosaccharides identified include arabinose, galacturonic acid, rhamnose, galactose, and glucose.
  • Significant in vitro antioxidant activity was observed.
  • Potent inhibition of pancreatic lipase, α-amylase, and α-glucosidase was demonstrated, with low IC50 values for lipase inhibition.

Conclusions:

  • The study establishes a correlation between the structural characteristics (monosaccharide composition, molecular weight) and bioactivity of blue honeysuckle polysaccharides.
  • These polysaccharides exhibit promising potential as functional food ingredients for managing hyperglycemia and obesity.
  • Novel insights into the structure-activity relationships of these compounds were provided.