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The Oral Microbiota01:27

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Updated: Apr 15, 2026

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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The Interplay Between Periodontitis and Atrial Fibrillation: Inflammation as a Common Pathophysiological Bridge.

Francesco Caprino1, Andrea Filardo2, Jessica Bria2

  • 1Department of Experimental and Clinical Medicine, University Magna Græcia, 88100 Catanzaro, Italy.

International Journal of Molecular Sciences
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Periodontitis (PD) and atrial fibrillation (AF) are linked by inflammation. Treating gum disease may reduce AF risk, highlighting oral health

Keywords:
atrial fibrillationchronic inflammationimmune responseinflammasomemicrobial dysbiosisperiodontitis

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Area of Science:

  • Cardiovascular Research
  • Oral Health Science
  • Immunology

Background:

  • Periodontitis (PD) and atrial fibrillation (AF) are prevalent chronic conditions.
  • Emerging evidence suggests a link between PD and AF, primarily through shared inflammatory and immune pathways.

Purpose of the Study:

  • To review the current evidence elucidating the relationship between periodontitis and atrial fibrillation.
  • To emphasize the role of periodontal health in cardiovascular disease prevention.

Main Methods:

  • Synthesis of clinical, epidemiological, molecular, and experimental data.
  • Analysis of studies investigating the association between PD and AF incidence/recurrence.
  • Examination of mechanistic insights from experimental models.

Main Results:

  • Moderate to severe PD is associated with a higher incidence and recurrence of AF, independent of other risk factors.
  • Periodontal pathogens like Porphyromonas gingivalis and immune dysregulation are implicated.
  • Inflammation-driven atrial fibrosis and immune activation are key linking mechanisms.

Conclusions:

  • Periodontal inflammation can lead to atrial remodeling and electrical disturbances, predisposing to AF.
  • Improved oral hygiene and periodontal treatment may reduce AF risk.
  • Periodontal health is a potential target for cardiovascular disease prevention strategies.