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Updated: Jun 19, 2026

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
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Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

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Special Issue "Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction"

Clemens Gögele1, Gundula Schulze-Tanzil1

  • 1Institute of Anatomy and Cell Biology, Paracelsus Medical University, 90419 Nuremberg, Germany.

International Journal of Molecular Sciences
|April 14, 2026
PubMed
Summary

Connective tissues like ligaments, tendons, and cartilage have limited blood supply and few cells, primarily consisting of a specialized extracellular matrix (ECM) rich in collagen.

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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...