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Updated: Apr 15, 2026

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting
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Published on: December 9, 2022

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Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network

Dan Dumitrescu1,2, Stefan Oprea1,3, Raluca Tulin1,3

  • 1Faculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

International Journal of Molecular Sciences
|April 14, 2026
PubMed
Summary

Chloride regulation in microdomains controls brain inhibition. Disruptions in chloride homeostasis cause neurological disorders, but targeting these microdomains offers new therapeutic strategies.

Keywords:
astrocytic bufferingchloride microdomainscortical hyperexcitabilitygabaergic polarityinhibitory instabilitykcc2 regulationnkcc1 reactivation

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