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Role of Exercise in Modulating the Brain-Heart Axis in Cardiovascular Diseases
Wenyan Bo1, Qingxiang Guo1, Yixuan Ma2
1Institute of Physical Education, Shanxi University, Taiyuan 030006, China.
International Journal of Molecular Sciences
|April 14, 2026
Summary
Regular exercise helps prevent cardiovascular diseases (CVDs) by modulating the brain-heart axis. This review explores how exercise impacts this axis for CVD prevention and treatment, considering exercise variables and risks.
Area of Science:
- Cardiology
- Neuroscience
- Exercise Physiology
Background:
- Cardiovascular diseases (CVDs) pose a significant health burden.
- The brain-heart axis plays a crucial role in CVD onset and progression.
- Mechanisms of exercise-induced cardioprotection are not fully understood.
Purpose of the Study:
- To review the role of brain-heart axis dysfunction in CVDs.
- To discuss how exercise modulates the brain-heart axis for cardiovascular protection.
- To examine exercise prescription variables and risks related to the brain-heart axis.
Main Methods:
- Systematic literature review.
- Analysis of pathophysiological mechanisms.
- Discussion of exercise physiology and clinical implications.
Main Results:
- Brain-heart axis dysfunction is implicated in CVD development.
- Exercise can protect the heart by regulating the brain-heart axis.
- Exercise prescription variables influence brain-heart axis modulation.
Conclusions:
- Exercise is a key factor in CVD prevention and treatment via the brain-heart axis.
- Understanding exercise's impact on the brain-heart axis can inform precision medicine.
- Further research is needed to optimize exercise strategies for CVD management.
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