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Platelet Apoptosis in Patients with Coronary Artery Disease Before and After CABG

Arkadiy A Metelkin1, Ekaterina A Sergeeva1, Mikhail A Popov2

  • 1Department of Molecular and Cellular Pathophysiology, Research Institute of General Pathology and Pathophysiology, Baltiyskaya 8, 125315 Moscow, Russia.

International Journal of Molecular Sciences
|April 14, 2026
PubMed

Insights

Platelet apoptosis, a process of programmed cell death, changes significantly after coronary artery bypass graft (CABG) surgery. These dynamics in platelet function may help predict cardiovascular disease outcomes and complications.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Cellular Biology

Background:

  • Cardiovascular diseases, including coronary artery disease, are a leading global cause of mortality.
  • Predicting long-term outcomes after coronary artery bypass graft (CABG) surgery remains challenging.
  • Platelet function is integral to cardiovascular disease progression and may predict postoperative complications.

Purpose of the Study:

  • To investigate the changes in platelet apoptosis before and after CABG surgery.
  • To explore the role of platelet apoptosis in coronary artery disease and atherosclerosis.
  • To assess the potential of platelet apoptosis dynamics in predicting postoperative complications.

Main Methods:

  • Flow cytometry, Western blot, and polymerase chain reaction were employed.
  • Evaluation of platelet apoptosis and activation markers.
  • Assessment of platelet membrane changes and mitochondrial membrane depolarization.

Main Results:

  • Significant changes in platelet apoptosis dynamics were observed post-CABG.
  • Evidence of apoptosis activation via an extrinsic receptor-dependent pathway, including caspase 8 and BCL-2 expression.
  • Alterations in platelet membrane and mitochondrial membrane potential were detected.

Conclusions:

  • Platelet apoptosis plays a significant role in the pathophysiology of coronary artery disease and atherosclerosis.
  • Changes in platelet metabolic processes and apoptosis are linked to postoperative complications after CABG.
  • Platelet apoptosis dynamics offer potential as a predictive marker for cardiovascular disease outcomes.

Keywords:
apoptosiscardiovascular diseasecoronary heart diseaseplatelets

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