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Association Between Vitamin D Deficiency, Malnutrition, and Systemic Inflammation in Advanced Colorectal Cancer: A
Daylia Thet1, Chidchanok Rungruang2, Nutthada Areepium2
1Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Vitamin D deficiency and malnutrition are common in advanced colorectal cancer (CRC) patients, often linked with inflammation. Albumin levels may help identify these conditions, suggesting comprehensive nutritional assessment is vital.
Area of Science:
- Oncology
- Nutritional Science
- Biochemistry
Background:
- Vitamin D deficiency and malnutrition are prevalent issues in colorectal cancer (CRC) patients, potentially worsening outcomes.
- These conditions may be interconnected with systemic inflammation and biochemical markers in advanced CRC.
Purpose of the Study:
- To conduct an integrative analysis of serum vitamin D, nutritional status, anthropometry, and biochemical profiles in advanced CRC patients.
- To explore the relationships between these parameters and identify potential indicators for malnutrition and vitamin D deficiency.
Main Methods:
- Inclusion of 58 advanced CRC patients.
- Measurement of serum vitamin D, nutritional status (Mini Nutritional Assessment - MNA), body composition, and handgrip strength.
- Analysis of biochemical and clinical data using correlation, regression, and ROC analyses.
Main Results:
- High prevalence of abnormal nutritional status (55.17%), vitamin D deficiency (50.00%), and sarcopenia (29.31%) observed.
- Negative correlation found between serum vitamin D and absolute neutrophil count (ANC).
- Albumin levels showed significant association with both serum vitamin D and MNA scores, and demonstrated potential in ROC analyses for identifying malnutrition and vitamin D deficiency.
Conclusions:
- Vitamin D deficiency, malnutrition, and systemic inflammation frequently coexist and are interrelated in advanced CRC.
- Comprehensive nutritional assessment is recommended for advanced CRC patients within supportive care settings.
- Albumin may serve as a potential biomarker for nutritional status and vitamin D levels in this population.
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