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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Ginger Bioactives as Multi-Target Therapeutics: Mechanisms, Delivery Innovation, and Human Health Impact.

Pasquale Simeone1, Francesca Martina Filannino1, Antonia Cianciulli2

  • 1Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.

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Summary

Ginger

Keywords:
Zingiber officinale Roscoeanti-apoptoticanti-inflammatoryartificial intelligencebioactive compoundsgingergingerolhealthnanotechnologynutraceuticalshogaol

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Nanotechnology

Background:

  • Ginger is a traditional medicinal plant with bioactive compounds studied for therapeutic potential.
  • Nanotechnology enhances the bioavailability and efficacy of ginger compounds in modern medicine.

Purpose of the Study:

  • To review ginger's therapeutic potential in disease prevention and management.
  • To explore molecular mechanisms and anti-aging properties of ginger compounds.

Main Methods:

  • Comprehensive literature review of relevant studies.
  • Identification through research databases, screening, and manual checks.

Main Results:

  • Ginger compounds show potential for cardiovascular, arthritis, neurodegenerative, and gastrointestinal diseases.
  • Evidence is mainly preclinical, with limited clinical data; AI aids discovery.

Conclusions:

  • Ginger extracts have emerging applications in human health.
  • Ginger holds potential for traditional medicine and contemporary drug discovery.