Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

6.2K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating imidazole propionate and coronary heart disease risk: interplay between histidine intake, fiber, and gut microbiome.

BMC medicine·2026
Same author

Inference for Stationary Log-Gaussian Cox Point Processes using Bayesian Deep Learning: Application to Human Oral Microbiome Image Data.

Spatial statistics·2026
Same author

Sequential gemcitabine and panobinostat-loaded albumin nanoparticle delivery via thermosensitive hydrogel in pancreatic peritoneal metastasis.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Epidemiological and Multi-Omics Investigation of Phytosterol Intake and Type 2 Diabetes Risk.

Research square·2026
Same author

Intake of Fiber From Different Food Sources and Type 2 Diabetes Risk: An Integrated Analysis of Epidemiological and Multiomic Data.

Diabetes care·2026
Same author

Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.

Statistics in medicine·2026

Related Experiment Video

Updated: Apr 15, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

4.5K

Cocoa Powder Modulates HIF-1α Stability and Inhibits Ocular Angiogenic and Degenerative Pathology.

Su Jung Hwang1, InWha Park1, Yeo Jin Sa2

  • 1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Nutrients
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Cocoa powder (CP) suppresses hypoxia-driven inflammation and pathological angiogenesis, protecting against vascular degeneration. This dietary intervention supports tissue preservation in conditions like retinal degeneration.

Keywords:
HIF-1α signalingangiogenesiscocoa powdercorneal neovascularizationdietary polyphenolsendothelial regenerationmetabolic reprogrammingretinal degenerationtissue remodelingvascular inflammation

More Related Videos

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.7K
Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images
04:04

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Published on: May 19, 2023

1.4K

Related Experiment Videos

Last Updated: Apr 15, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

4.5K
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.7K
Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images
04:04

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Published on: May 19, 2023

1.4K

Area of Science:

  • Nutritional science
  • Vascular biology
  • Ophthalmology

Background:

  • Vascular inflammation and poor endothelial regeneration drive chronic degenerative diseases, including ocular neovascularization and retinal degeneration.
  • Nutritional bioactives offer potential therapeutic strategies by modulating angiogenesis and tissue remodeling pathways.

Purpose of the Study:

  • To investigate cocoa powder's (CP) effects on hypoxia-induced molecular signaling.
  • To assess CP's capacity to reduce vascular inflammation and degeneration in ocular models.

Main Methods:

  • Examined CP's vascular effects in human umbilical vein endothelial cells (HUVECs) and murine models of corneal neovascularization and retinal degeneration.
  • Assessed hypoxia-inducible factor-1α (HIF-1α) signaling, angiogenic responses, and in vivo vascular/retinal integrity.
  • Utilized Western blotting, qPCR, cell assays, histology, immunofluorescence, and protein expression analysis.

Main Results:

  • CP suppressed hypoxia-induced HIF-1α stabilization and reduced key angiogenic factors (VEGFA, EPO, GLUT1) without cytotoxicity.
  • CP inhibited endothelial cell migration, network formation, and invasion.
  • In vivo, CP reduced corneal neovascularization, vascular inflammation, and fibrotic remodeling, while preserving retinal structure and function in a degeneration model.

Conclusions:

  • Cocoa powder acts as a nutritional modulator of hypoxia-responsive and inflammatory pathways.
  • CP suppresses pathological angiogenesis and supports structural integrity in degenerative vascular conditions.
  • Dietary polyphenol-rich interventions show translational potential for vascular inflammation and regeneration.