Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.7K
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

2.3K
The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
2.3K
Concepts of Health and Illness01:29

Concepts of Health and Illness

20.2K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
20.2K
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

468
Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
468
Factors Affecting Illness01:18

Factors Affecting Illness

5.7K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.7K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

8.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Employee preferences in health plan design: results from a national survey.

Health affairs scholar·2026
Same author

Evidence available and used by the Food and Drug Administration for the approval of orphan and nonorphan drugs.

Health affairs scholar·2025
Same author

Sex Distribution of Clinical Trial Participants: How Often Are Women Excluded?

Journal of general internal medicine·2025
Same author

A global context for population mental health: Commentary on Dodge et al. (2024).

The American psychologist·2024
Same author

Food and Drug Administration novel drug decisions in 2017: transparency and disclosure prior to and 5 years following approval.

Health affairs scholar·2024
Same author

Cost-effectiveness evaluations should be based on trials, not models.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2024

Related Experiment Video

Updated: Apr 15, 2026

Inoculating Anopheles gambiae Mosquitoes with Beads to Induce and Measure the Melanization Immune Response
08:24

Inoculating Anopheles gambiae Mosquitoes with Beads to Induce and Measure the Melanization Immune Response

Published on: January 12, 2017

8.4K

Does the relationship between health and behavior depend on changes in immune functioning?

Robert M Kaplan1

  • 1Clinical Excellence Research Center, Stanford University School of Medicine, Stanford, CA, United States.

Translational Behavioral Medicine
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Behavioral interventions may not improve health by altering immune function. Focus should shift to patient-centered outcomes like quality of life and longevity for better health benefits.

Keywords:
immune functionpatient-reported outcomes (PROs)psychoneuroimmunologysurrogate markers

More Related Videos

Mouse Short- and Long-term Locomotor Activity Analyzed by Video Tracking Software
10:15

Mouse Short- and Long-term Locomotor Activity Analyzed by Video Tracking Software

Published on: June 20, 2013

21.0K
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

2.5K

Related Experiment Videos

Last Updated: Apr 15, 2026

Inoculating Anopheles gambiae Mosquitoes with Beads to Induce and Measure the Melanization Immune Response
08:24

Inoculating Anopheles gambiae Mosquitoes with Beads to Induce and Measure the Melanization Immune Response

Published on: January 12, 2017

8.4K
Mouse Short- and Long-term Locomotor Activity Analyzed by Video Tracking Software
10:15

Mouse Short- and Long-term Locomotor Activity Analyzed by Video Tracking Software

Published on: June 20, 2013

21.0K
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

2.5K

Area of Science:

  • Psychoneuroimmunology
  • Behavioral Medicine
  • Health Psychology

Background:

  • Psychoneuroimmunology investigates how stress and behaviors impact disease risk via immune mechanisms.
  • Relies on biomarkers like cytokines, cortisol, and natural killer cell activity to explain health outcomes.

Purpose of the Study:

  • Critically evaluate if behavioral and psychological interventions enhance health outcomes by modifying immune function.
  • Assess the role of immune markers as mediators of behavioral health benefits.

Main Methods:

  • Systematic reviews, landmark reports, and conceptual frameworks from the past 80 years were analyzed.
  • Examined evidence on whether immune marker modification translates to improved patient-centered health outcomes.

Main Results:

  • Stress and social adversity correlate with immune parameters, but modifying these markers hasn't reliably improved patient outcomes in randomized trials.
  • Behavioral interventions likely benefit health through mechanisms other than immune modulation.

Conclusions:

  • Behavioral medicine should prioritize patient-meaningful outcomes over surrogate immunologic markers.
  • Future research should focus on functional capacity, health-related quality of life, and life expectancy as primary endpoints.