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Rising dementia mortality among tobacco users in the US, 2005-2020: insights from CDC-WONDER database
Maryam Saghir1, Muhammad Affan1, Eshal Saghir2
1Department of Internal Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Neurodegenerative Disease Management
|April 14, 2026
Summary
Deaths from dementia among tobacco users surged significantly in the U.S. between 2005 and 2020. This trend shows disparities across sex, race, and region, emphasizing the need for smoking cessation and dementia care interventions.
Area of Science:
- Gerontology
- Public Health
- Epidemiology
Background:
- Dementia is a major health concern in aging populations.
- Tobacco use is a significant, modifiable risk factor for dementia.
- National trends in dementia mortality among tobacco users are not well understood.
Purpose of the Study:
- To analyze national trends in dementia mortality among tobacco users in the U.S.
- To identify demographic and geographic disparities in dementia deaths among tobacco users.
Main Methods:
- Analysis of the CDC WONDER database (2005-2020).
- Calculation of age-adjusted mortality rates (AAMR) per 100,000 population.
- Use of Joinpoint regression to assess mortality trends.
Main Results:
- Over 63,000 dementia deaths among tobacco users (≥65 years) were recorded.
- Age-adjusted mortality rates due to dementia among tobacco users increased from 3.25 to 12.87.
- Higher mortality rates were observed in men, Non-Hispanic White individuals, the Midwest region, and non-metropolitan areas.
Conclusions:
- Dementia deaths linked to tobacco use have sharply increased in the U.S.
- Significant disparities exist based on sex, race, and geographic location.
- Urgent need for targeted smoking cessation and equitable dementia care strategies.
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