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A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
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Biosensor Compared With Standard Care to Identify Extravasation Injuries in Paediatric Intensive Care: A Randomised

Craig A McBride1,2,3,4, Sarfaraz Rahiman5, Melanie Kennedy5

  • 1Surgical Team: Infants, Toddlers, Children (STITCh), Queensland Children's Hospital, South Brisbane, Queensland, Australia.

Journal of Paediatrics and Child Health
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

A biosensor monitoring system did not significantly reduce extravasation injuries in children receiving high-risk intravenous medications in paediatric intensive care units (PICU). The tissue-infiltration biosensor technology was found to be acceptable for use by nursing staff.

Keywords:
extravasationivWatchpaediatric intensive carevesicant medication

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Area of Science:

  • Pediatric Intensive Care
  • Medical Device Technology
  • Patient Safety

Background:

  • Peripheral venous access devices (PVADs) are crucial in pediatric intensive care units (PICUs).
  • Extravasation injuries, a risk with PVADs, can lead to significant harm.
  • Monitoring technology aims to improve early detection and prevention of these injuries.

Purpose of the Study:

  • To assess if a tissue-infiltration biosensor (ivWatch) reduces extravasation injuries in pediatric patients receiving intermediate- or high-risk medications via PVADs.
  • To compare the efficacy of biosensor monitoring plus standard care against standard care alone in preventing extravasation harm.
  • To evaluate the usability and acceptance of the biosensor technology by nursing staff.

Main Methods:

  • A randomized controlled trial was conducted in a single quaternary hospital PICU.
  • 175 children with PVADs receiving high-risk infusates were randomized to either biosensor monitoring or standard care.
  • The primary outcome was extravasation severity, measured using the Cincinnati Children's Hospital Medical Centre Extravasation Harm Scale.

Main Results:

  • No statistically significant difference in extravasation severity was found between the biosensor group (n=88) and the standard care group (n=87).
  • Injury rates (no, mild, moderate) were comparable across both groups.
  • No significant differences were observed in extravasation volume, treatment sequelae, or device dwell time.

Conclusions:

  • Biosensor monitoring, when added to standard care, did not significantly decrease extravasation injuries in this PICU population.
  • The ivWatch biosensor system demonstrated acceptability among bedside nursing staff.
  • Further research may be needed to explore the role of biosensors in pediatric patient safety.