Related Experiment Video
Updated: Apr 15, 2026

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
Published on: January 26, 2024
Association of Serum 25-Hydroxyvitamin D and Vitamin D Receptor Gene Variants With Dengue Severity in Vietnamese
Hung Viet Phan1,2, Hieu Lan Nguyen3, Thuy Thi Dieu Nguyen1
1Hanoi Medical University, Vietnam.
Objective:
To investigate the association of serum 25(OH)D levels with dengue severity in Vietnamese children and the association of common VDR gene polymorphisms with disease outcomes.
Methods:
This cross-sectional study included 178 children with confirmed dengue at a tertiary hospital in 2024. Serum 25(OH)D levels were measured, and 4 VDR polymorphisms (FokI, ApaI, TaqI, BsmI) were genotyped. Associations with WHO-defined severity were assessed using logistic regression.
Results:
Severe dengue was more common in older children and was characterized by greater plasma leakage and thrombocytopenia (P < .001). Serum 25(OH)D concentrations were independently and inversely associated with dengue severity, with an adjusted odds ratio of 0.89 (95% CI: 0.85-0.93; P < .001). In contrast, allele and genotype distributions of the 4 VDR polymorphisms did not differ significantly across severity groups (P > .05).
Conclusion:
Our findings suggest vitamin D status may be more relevant to dengue severity than inherited VDR variation.
More Related Videos
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
08:36Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...