Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathological and immunohistochemical profile of breast lesions diagnosed by core needle biopsy: a retrospective study from Sf. Ioan Hospital, Bucharest, Romania.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie·2026
Same author

Functional Recovery and Emotional Burden After Burn Injury: A Quality of Life Assessment in Romanian Burn Survivors.

Diseases (Basel, Switzerland)·2026
Same author

Minimally Invasive Versus Open Total Hysterectomy: From Practice Variability to a Decision Algorithm.

Life (Basel, Switzerland)·2026
Same author

Labial Adhesion-An Uncommon Adult Condition: Clinical Features, Management and Histopathological Findings-A Case Series Study.

Life (Basel, Switzerland)·2026
Same author

Quality of Life and Functional Outcomes After Rectal Cancer Surgery: A Comparative Study Applying EORTC QLQ-C30, QLQ-CR29, and LARS Score at 1-6 Months Postoperatively.

Healthcare (Basel, Switzerland)·2026
Same author

The Concerning Lack of Mammography in the Early Detection of Breast Cancer in Romania.

Chirurgia (Bucharest, Romania : 1990)·2026

Related Experiment Video

Updated: Jun 29, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.8K

Genetic Testing in Breast Cancer: Narrative Review and Clinical Insights.

Iulia Bistriceanu1,2, Claudiu-Octavian Ungureanu1,2, Razvan-Andrei Stoica1,2

  • 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Maedica
|April 14, 2026
PubMed
Summary

Identifying hereditary breast cancer through germline pathogenic variants is crucial. Multigene panels enhance risk assessment and treatment, but access and interpretation challenges persist.

Keywords:
BRCA1BRCA2PARP inhibitorsgenetic counsellinggenetic testinghereditary breast cancermultigene panels

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.7K
Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

758

Related Experiment Videos

Last Updated: Jun 29, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.8K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.7K
Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

758

Area of Science:

  • Oncology
  • Genetics
  • Cancer Research

Background:

  • Germline pathogenic variants in hereditary breast cancer genes significantly impact cancer risk, surveillance, and treatment.
  • While BRCA1 and BRCA2 are key, clinical practice is evolving towards broader multigene testing.
  • Understanding these variants is vital for personalized cancer care.

Purpose of the Study:

  • To review the molecular basis of hereditary breast cancer.
  • To examine current genetic testing strategies and guideline indications.
  • To explore the challenges associated with genetic risk disclosure.

Main Methods:

  • Literature review of recent advancements in hereditary breast cancer genetics.
  • Analysis of next-generation sequencing (NGS)-based multigene panel testing.
  • Assessment of psychological, ethical, and social aspects of genetic risk disclosure.

Main Results:

  • NGS multigene panels efficiently identify high- and moderate-penetrance variants, aiding personalized screening and treatment, including PARP inhibitor eligibility.
  • Clinical implementation faces barriers like variants of uncertain significance and unequal access to genetic services.
  • Genetic testing is transforming breast cancer management.

Conclusions:

  • Genetic testing integrates prevention and precision oncology in breast cancer care.
  • Improving access to genetic counseling and testing is essential.
  • Optimizing variant interpretation is key to realizing genomic benefits in clinical practice.