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A harmonized framework for studying exceptional cognitive aging in Latin America.

Lucia Crivelli1, Rodrigo Fernandez2,3, Nicolas Corvalán1

  • 1Departamento de Neurología Cognitiva, Fleni, Buenos Aires, Argentina.

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Summary
This summary is machine-generated.

The Life-Course Epidemiology of Aging, Resilience, and Neurodegeneration in Alzheimer's Disease (LEARN-AD) and Latin American SuperAgers Study (LASAS) create frameworks to explore cognitive resilience in Latin America. These studies will generate vital data for brain health research and prevention strategies.

Keywords:
Latin AmericaSuperAgersexceptional memory aging phenotypehealthy cognitive agingresilienceresistancesuccessful cognitive aging

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Area of Science:

  • Neuroscience
  • Epidemiology
  • Gerontology

Background:

  • Factors influencing cognitive resilience and resistance to neurodegenerative diseases are understudied in Latin America.
  • The Life-Course Epidemiology of Aging, Resilience, and Neurodegeneration in Alzheimer's Disease (LEARN-AD) and Latin American SuperAgers Study (LASAS) are introduced as novel research initiatives.
  • These studies aim to establish harmonized frameworks for characterizing cognitive resilience and exceptional cognitive aging phenotypes within the region.

Purpose of the Study:

  • To define eligibility criteria and standardized assessments for classifying successful cognitive agers and SuperAgers in Latin America.
  • To investigate the biological and psychosocial profiles associated with better-than-expected cognitive function.
  • To establish the first Latin American infrastructure for studying cognitive resilience and resistance to pathology.

Main Methods:

  • Integration of cognitive, neurological, psychosocial, and genetic data through a shared protocol.
  • Deep phenotyping of SuperAgers and harmonized criteria for identifying successful cognitive agers in existing cohorts.
  • Centralized training and standardized procedures to ensure cross-site consistency and international comparability.

Main Results:

  • Development of eligibility criteria and standardized assessments for identifying successful cognitive agers and SuperAgers in Latin America.
  • Examination of biological and psychosocial factors that support superior cognitive function in aging populations.
  • Establishment of a foundation for understanding cognitive aging phenotypes specific to the Latin American region.

Conclusions:

  • LEARN-AD and LASAS represent pioneering Latin American infrastructure for cognitive resilience and exceptional aging research.
  • These studies will generate unique regional databases and foster larger research networks.
  • The findings will inform future research, prevention strategies, and precision approaches to promote brain health in Latin America.