Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Condensins02:15

Condensins

2.3K
2.3K
Condensins02:15

Condensins

5.0K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
5.0K
Nucleic Acid Structure01:25

Nucleic Acid Structure

10.4K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
10.4K
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

7.4K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
7.4K
Nucleic Acids02:43

Nucleic Acids

52.5K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
52.5K
Nucleic acids02:43

Nucleic acids

199.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
199.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solitary intracranial metastasis as the sole relapse site in gastric cancer patients after neoadjuvant therapy and surgery: a case series of 12 patients and clinical implications.

Frontiers in oncology·2026
Same author

Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice.

Nature communications·2026
Same author

Network Pharmacology Analysis and Experimental Study of Yinchen Against Neuroinflammation in Ischemic Stroke.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Spinal infection caused by <i>Aspergillus terreus</i> in immunocompetent individuals: a case report and literature review.

Frontiers in medicine·2025
Same author

Camera Trap Dataset of Rodents and Sympatric Vertebrates in the Desert Steppe of Qilian Mountains China.

Scientific data·2025
Same author

Relationship between knee isokinetic muscle strength and countermovement jump height among elite male gymnasts.

Frontiers in sports and active living·2025

Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.6K

Construction and Application of Nucleic Acids-Based Biomolecular Condensates.

Yijie Ma1, Kewei Ren1

  • 1School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.

Accounts of Chemical Research
|April 14, 2026
PubMed
Summary

Scientists engineer synthetic biomolecular condensates using programmable nucleic acids. These engineered condensates offer precise control for applications in biosensing and cellular regulation.

More Related Videos

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.8K
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.8K

Related Experiment Videos

Last Updated: Apr 15, 2026

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.6K
Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.8K
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.8K

Area of Science:

  • Biochemistry and Molecular Biology
  • Synthetic Biology
  • Biomaterials Science

Background:

  • Biomolecular condensates are membrane-less organelles crucial for cellular organization and regulation.
  • Liquid-liquid phase separation (LLPS) drives the formation of these dynamic structures.
  • Engineering synthetic condensates aids in understanding biological processes and disease mechanisms.

Purpose of the Study:

  • To provide an overview of nucleic acid-based biomolecular condensates.
  • To discuss the principles governing their formation and applications.
  • To highlight future opportunities in this field.

Main Methods:

  • Utilizing nucleic acids' programmability and Watson-Crick base pairing for condensate assembly.
  • Designing and modifying nucleic acid sequences to control condensate formation and decomposition.
  • Employing multivalent interactions in nucleic acid or nucleic acid-peptide complexes.

Main Results:

  • Demonstrated nucleic acid-based condensates for enhanced RNA aptamer properties.
  • Developed condensates for detecting biomolecules and target cells.
  • Applied condensates for intracellular target RNA recruitment and cellular regulation.

Conclusions:

  • Nucleic acid-based condensates offer a versatile platform for synthetic biology applications.
  • Precise control over condensate formation enables diverse applications in biosensing and cell regulation.
  • Further research holds promise for advancements in cell biology and biomedicine.