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Updated: Apr 15, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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When Selectivity Increases Uncertainty: Context-Dependent Pharmacology in Antibody Drug Development

Xiaozhi Liao1, Yanguang Cao1

  • 1Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel, USA.

Clinical and Translational Science
|April 14, 2026
PubMed
Summary

Highly selective antibody therapeutics exhibit context-dependent pharmacology, complicating drug development. Understanding this biological context is crucial for accurate translation, dosing, and combination therapy selection for biologics.

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