Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

12.0K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
12.0K
Microbiome of the Eye01:22

Microbiome of the Eye

58
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
58
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

4.7K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
4.7K
Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A sonosensitizing hydrogel with tumour-confined stability for intrinsically targeted sonodynamic therapy.

Biomaterials·2026
Same author

Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation.

Atherosclerosis·2026
Same author

Novel CRISPR-Cas9 BAP1 knockout pre-clinical tumor model recapitulates human melanoma tumorigenesis and immune evolution.

Communications biology·2026
Same author

Geometry-aware PointNet for rapid prediction of cerebral aneurysm hemodynamics.

Computer methods and programs in biomedicine·2026
Same author

Non-Invasive functional assessment of severity in cerebral arterial stenosis using cerebral flow fraction: A hemodynamic study.

Medical & biological engineering & computing·2026
Same author

In vitro and in vivo validation of a novel 3D-printed vessel anastomosis device for microvascular surgery.

Scientific reports·2026

Related Experiment Video

Updated: Apr 15, 2026

Enrichment of Bruch's Membrane from Human Donor Eyes
10:22

Enrichment of Bruch's Membrane from Human Donor Eyes

Published on: November 15, 2015

12.7K

Bruch's Membrane Contributes to the Structural Integrity of the Normal Human Eye.

Royston K Y Tan1,2, Swati Sharma1, Anita S Y Chan1,2,3

  • 1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Investigative Ophthalmology & Visual Science
|April 14, 2026
PubMed
Summary

The Bruch's membrane-choriocapillaris (BMC) complex significantly contributes to ocular wall strength, despite being thinner than the sclera. This finding is crucial for understanding eye biomechanics and structural integrity.

More Related Videos

Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
08:32

Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane

Published on: April 12, 2018

10.9K
Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry
05:15

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

Published on: October 20, 2019

9.5K

Related Experiment Videos

Last Updated: Apr 15, 2026

Enrichment of Bruch's Membrane from Human Donor Eyes
10:22

Enrichment of Bruch's Membrane from Human Donor Eyes

Published on: November 15, 2015

12.7K
Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
08:32

Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane

Published on: April 12, 2018

10.9K
Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry
05:15

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

Published on: October 20, 2019

9.5K

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Materials Science

Background:

  • The ocular wall's structural integrity is vital for maintaining eye shape and function.
  • Understanding the biomechanical contributions of different ocular tissues is essential for diagnosing and treating eye diseases.

Purpose of the Study:

  • To investigate the biomechanical contribution of Bruch's membrane and sclera to the ocular wall's structural integrity.
  • To compare the mechanical properties of the Bruch's membrane-choriocapillaris (BMC) complex and sclera.

Main Methods:

  • Biomechanical testing of 23 human globes.
  • Intraocular pressure (IOP) was increased until the Bruch's membrane-uvea-retina (BMUR) layer ruptured.
  • Uniaxial tension tests were performed on isolated sclera and BMC strips.

Main Results:

  • The BMUR ruptured at a high IOP of 98.1 ± 21.4 mm Hg.
  • BMC tangent moduli were approximately three times higher than sclera moduli at strains of 0.01 and 0.02.
  • Despite being thinner, BMC contributes significantly to ocular wall strength.

Conclusions:

  • The BMUR can withstand substantial IOP.
  • The BMC complex plays a critical role in ocular structural strength, comparable to the thicker sclera.
  • Further research into BMC biomechanics can inform treatments for conditions affecting ocular integrity.