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Histopathological Signatures Associated With Postoperative Recurrence in Pediatric Chronic Rhinosinusitis With Nasal
Shenghao Cheng1,2,3,4, Zongjing Tong5,6, Lai Meng1,2,3,4
1Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, China.
Summary
Pediatric chronic rhinosinusitis with nasal polyps (CRSwNP) often recurs after surgery. Goblet cell hyperplasia and basement membrane thickening are key pathological features linked to recurrence in children with CRSwNP.
Area of Science:
- Otolaryngology
- Pathology
- Pediatric Respiratory Medicine
Background:
- Pediatric chronic rhinosinusitis with nasal polyps (CRSwNP) has a high recurrence rate post-surgery.
- Histopathological factors influencing recurrence in pediatric CRSwNP remain poorly understood.
Purpose of the Study:
- To investigate histopathological determinants associated with postoperative recurrence in pediatric CRSwNP.
- To identify mechanisms driving persistent disease in pediatric CRSwNP.
Main Methods:
- Retrospective clinical study involving 228 pediatric CRSwNP patients.
- Systematic assessment of clinical variables and histopathological features.
- Follow-up exceeding 2 years to classify patients into recurrent (rCRSwNP) and non-recurrent (non-rCRSwNP) groups.
- Statistical analysis using Cox regression and Kaplan-Meier survival analyses.
Main Results:
- 153 patients were classified as rCRSwNP and 75 as non-rCRSwNP.
- Allergic rhinitis comorbidity was more frequent in the rCRSwNP group.
- Goblet cell hyperplasia and basement membrane thickening were significantly more pronounced in the rCRSwNP group.
- Severity of goblet cell hyperplasia emerged as an independent predictor of recurrence.
Conclusions:
- Pediatric rCRSwNP is characterized by basement membrane thickening and goblet cell hyperplasia.
- The degree of goblet cell hyperplasia is a significant independent predictor of postoperative recurrence.
- Goblet cell hyperplasia serves as a clinically actionable marker for identifying high-risk pediatric CRSwNP patients.
