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Related Experiment Video

Updated: Apr 15, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

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TORCH: Current state of knowledge as of 2025.

Wioletta Edyta Pawlak-Zalewska1, Anna Monika Moniuszko1,1, Julia Matras1

  • 1Klinika Chorób Zakaźnych i Neuroinfekcji Uniwersytet Medyczny w Białymstoku.

Przeglad Epidemiologiczny
|April 14, 2026
PubMed
Summary

TORCH infections, including Toxoplasma gondii, Rubella, Cytomegalovirus (CMV), and Herpes simplex virus (HSV), pose risks during pregnancy. Standardized prenatal screening is crucial for early detection and management of these congenital infections.

Keywords:
CMVHSVRubellaToxoplasmosisTreponema pallidumZika Virusróżyczkatoxoplazmozavirus Zika

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Last Updated: Apr 15, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.9K

Area of Science:

  • Maternal-fetal medicine
  • Infectious diseases
  • Public health

Background:

  • TORCH infections (Toxoplasma gondii, Rubella, Cytomegalovirus, Herpes simplex virus) are significant causes of pregnancy complications.
  • The TORCH complex can include other pathogens like parvovirus B19 and Zika virus.
  • Prenatal screening practices for TORCH pathogens vary globally and are not universally implemented.

Purpose of the Study:

  • To review current knowledge on TORCH infections in pregnancy.
  • To provide practical guidance for healthcare professionals involved in prenatal care.
  • To highlight the importance of standardized screening protocols.

Main Methods:

  • Literature review of TORCH infections and their impact on pregnancy.
  • Analysis of current screening guidelines and practices, with a focus on Poland.
  • Discussion of diagnostic procedures within the Polish Standard of Perinatal Care.

Main Results:

  • Screening during pregnancy is vital for identifying unrecognized infections.
  • Standardized antenatal testing in Poland leads to new diagnoses of infections like HIV, HBV, and HCV among young women.
  • The Polish Standard of Perinatal Care outlines a unified set of investigations for prenatal diagnostics.

Conclusions:

  • Early detection of TORCH infections through prenatal screening is essential for preventing adverse pregnancy outcomes.
  • Standardized serological screening during pregnancy is more effective than pre-conception diagnosis for certain infections.
  • Adherence to national guidelines ensures comprehensive prenatal care and infection detection.