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The Prevalence of Coagulation Factor Deficiency Among Pediatric Populations in Medina City, Saudi Arabia

Adel Abo Mansour, Ahmad Shaikh, Bejad Aljohni

    Clinical Laboratory
    |April 14, 2026
    PubMed

    Insights

    Coagulation factor deficiencies are common in children in Medina, Saudi Arabia. Early diagnosis and monitoring of platelet counts and coagulation profiles are crucial for managing inherited bleeding disorders.

    Area of Science:

    • Hematology
    • Pediatric Medicine
    • Genetics

    Background:

    • Coagulation factor deficiencies are inherited bleeding disorders impacting blood clotting.
    • These conditions result from insufficient or dysfunctional coagulation factors.
    • Prevalence and impact on pediatric patients in Medina, Saudi Arabia, were investigated.

    Purpose of the Study:

    • To determine the prevalence of coagulation factor deficiencies in pediatric patients.
    • To assess the impact of these deficiencies on platelet counts and coagulation parameters.
    • To provide insights into bleeding disorder management in the region.

    Main Methods:

    • Retrospective analysis of 221 pediatric patients with coagulation factor deficiencies.
    • Inclusion of a control group of 50 healthy children for comparison.
    • Extraction of clinical and laboratory data including platelet count, PT, INR, APTT, and factor levels.

    Main Results:

    • Factor VIII (hemophilia A) and Factor IX (hemophilia B) were the most common deficiencies.
    • Significantly prolonged prothrombin time, INR, and APTT observed in deficient patients (p < 0.0001).
    • Prevalence was similar between males (50.22%) and females (49.78%).

    Conclusions:

    • High prevalence necessitates early diagnosis, genetic counseling, and specialized care.
    • Comprehensive management requires close monitoring of coagulation profiles and platelet counts.
    • Findings highlight the importance of monitoring in children with bleeding symptoms.
    Abstract

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