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Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Fungal secondary metabolites as a source of bioactive compounds: a modern approach to their acquisition and analysis
Piotr Michałowski1, Katarzyna Rynarzewska2, Dagmara Nowicka2
1Instytut Technologii i Inżynierii Chemicznej, Politechnika Poznańska, Poznań oraz Pracownia Chemii Medycznej, Centrum Biologii Chemicznej, Instytut Chemii Bioorganicznej Polskiej Akademii Nauk, Poznań.
Abstract:
Secondary metabolites, which are natural products of fungi, perform key biological functions and have applications in medicine. The production of these compounds is subject to the control of clusters of biosynthetic genes located within the genome. It has been observed that these genes can become dormant under standard culture conditions. The advent of modern genetic and epigenetic methodologies has rendered the activation of these elements possible, thus facilitating the identification of novel bioactive compounds. The present article delineates classes of metabolites, the mechanisms of their biosynthesis, and current research strategies, combining knowledge from biology, genetics, and biotechnology.
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