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Updated: Apr 15, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
Published on: May 18, 2009
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology
Simona Mattova1, Patrik Simko1, Elena Colzi2
1Department of Pathology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Rastislavova 43, 040 01, Košice, Slovakia.
Abstract:
P2X receptors, a family of ATP-gated ion channels, are increasingly recognized as key contributors to the pathophysiology of major depressive disorder. Among them, P2X7 plays a central role in stress-induced neuroinflammation by driving microglial activation, inflammasome signaling, and downstream reductions in BDNF and neuroplasticity. Additional P2X subtypes, including P2X4, further modulate neuronal and glial communication relevant to mood regulation. Evidence from animal models, human genetic studies, and early therapeutic trials supports the involvement of P2X signaling in depressive phenotypes and highlights P2X7 antagonists as promising candidates for novel antidepressant strategies. Overall, targeting P2X receptors offers a mechanistically distinct approach to understanding and treating depression.
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