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Related Experiment Video

Updated: Apr 16, 2026

Elevated Plus Maze for Mice
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Prelimbic Cortex Activity Predicts Anxiety-Like Behavior in the Elevated Plus Maze.

Marina A Smoak1,2, Karla J Galvan1,2, Daniel E Calvo3,4

  • 1Department of Biological Sciences, University of Texas at El Paso, USA.

The European Journal of Neuroscience
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

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Heightened prelimbic cortex activity in rats correlates with increased anxiety-like behaviors in the Elevated Plus Maze. This suggests the prelimbic cortex may regulate responses to threatening environments.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Emotional Regulation

Background:

  • The medial prefrontal cortex is crucial for emotional regulation.
  • Dysregulation of this area is linked to anxiety disorders.
  • The prelimbic cortex's specific role in anxiety is debated.

Purpose of the Study:

  • To investigate the role of the prelimbic cortex in anxiety-related behaviors.
  • To assess prelimbic neuronal activity during anxiety-provoking tasks.

Main Methods:

  • Endoscopic in vivo calcium imaging in male and female Sprague-Dawley rats.
  • Utilized the Elevated Plus Maze to measure anxiety-like behavior.

Main Results:

  • Rats spending less time in open arms showed higher prelimbic activity in open arms.
Keywords:
GCaMP6sanxietycalcium imagingmPFC (medial prefrontal cortex)prelimbic cortexrats

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Last Updated: Apr 16, 2026

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  • This suggests heightened prelimbic activity may indicate greater anxiety or avoidance.

    • Conclusions:

    • The prelimbic cortex may regulate emotional responses to anxiety-provoking situations.
    • It might influence tolerance to threatening environments.