Weekend Warrior Physical Activity Pattern, Metabolomic Profiles, and Risk of Osteoporosis and Fracture
Huan Huang1, Jiong Liu1, Peixuan Li2
1Department of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.
Summary
Engaging in moderate-to-vigorous physical activity (MVPA) as a weekend warrior significantly lowers osteoporosis and fracture risks. This pattern is linked to specific metabolites, offering insights into bone health benefits independent of genetic predisposition.
Area of Science:
- Bone health and physical activity research.
- Metabolomics and its role in exercise physiology.
- Epidemiology of osteoporosis and fracture risk.
Background:
- The weekend warrior physical activity pattern is increasingly prevalent.
- The impact of this pattern on osteoporosis and fracture risk is not well understood.
- Genetic susceptibility may influence bone health outcomes.
Purpose of the Study:
- To investigate the association between the weekend warrior physical activity pattern and bone health outcomes (osteoporosis, fracture).
- To identify specific metabolites linked to the weekend warrior pattern.
- To assess if genetic susceptibility modifies the relationship between physical activity patterns and bone health.
Main Methods:
- Analysis of accelerometer and metabolomic data from 14,069 UK Biobank participants.
- Identification of metabolomic signatures for weekend warrior and regular physical activity using elastic net regression.
- Cox proportional hazards models and stratified analyses by polygenic risk scores (PRS) to assess associations and effect modification.
Main Results:
- The weekend warrior pattern was associated with significantly reduced risks of osteoporosis (HR: 0.59) and fracture (HR: 0.77) compared to inactivity.
- Distinct metabolomic signatures were identified for weekend warrior and regular physical activity.
- Increased weekend warrior-related metabolomic signature correlated with lower osteoporosis (HR: 0.73) and fracture (HR: 0.88) risks.
- No significant modification of these associations by genetic susceptibility was observed.
Conclusions:
- The weekend warrior physical activity pattern demonstrates a protective effect against osteoporosis and fracture.
- Distinct metabolomic profiles characterize the weekend warrior pattern, suggesting potential mechanisms for its bone-protective benefits.
- These findings highlight the importance of accumulating sufficient physical activity, even if concentrated on weekends, for bone health.
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